Pop Cristina, Salvesen Guy S
Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, La Jolla, California 92037, USA.
Cell. 2005 Oct 21;123(2):192-3. doi: 10.1016/j.cell.2005.10.010.
Regulated apoptosis is part of the development of the nematode Caenorhabditis elegans. In a recent paper in Nature, Yan et al. (2005) describe the in vitro reconstitution of the core components of the worm apoptotic pathway. Based on a structural analysis of the complex between the death activator CED-4 and the antiapoptotic protein CED-9, the authors explain the regulation of activity of CED-4. Intriguingly, CED-4 comprises a AAA+ type ATPase domain yet does not seem to need ATP hydrolysis for activity.
受调控的细胞凋亡是线虫秀丽隐杆线虫发育过程的一部分。在最近发表于《自然》杂志的一篇论文中，Yan等人（2005年）描述了线虫凋亡途径核心成分的体外重建。基于对死亡激活因子CED - 4与抗凋亡蛋白CED - 9之间复合物的结构分析，作者解释了CED - 4活性的调控机制。有趣的是，CED - 4包含一个AAA +型ATP酶结构域，但似乎其活性并不需要ATP水解。
