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1
Alefacept for psoriasis and psoriatic arthritis.用于治疗银屑病和银屑病关节炎的阿法西普。
Ann Rheum Dis. 2005 Nov;64 Suppl 4(Suppl 4):iv58-60. doi: 10.1136/ard.2005.042655.
2
Alefacept: an expert review concerning the treatment of psoriasis.阿法西普：关于银屑病治疗的专家综述
Expert Opin Pharmacother. 2005 Oct;6(13):2327-33. doi: 10.1517/14656566.6.13.2327.
3
Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment.银屑病关节炎患者滑膜和皮损中白细胞介素-20的表达：对阿法赛特治疗的不同反应
Arthritis Res Ther. 2012 Sep 24;14(5):R200. doi: 10.1186/ar4038.
4
Alefacept. Amevive, BG 9273, human LFA-3/Igg fusion protein, LFA 3, LFA 3 TIP LFA 3/CD2, LFA-3/Igg fusion protein, LFA3TIP, recombinant LFA-3/Igg1 human fusion protein, recombinantly engineered LFA-1/Igg1 human fusion protein.阿法赛特。阿美维沃，BG 9273，人淋巴细胞功能相关抗原-3/免疫球蛋白融合蛋白，淋巴细胞功能相关抗原-3，淋巴细胞功能相关抗原-3 TIP，淋巴细胞功能相关抗原-3/CD2，淋巴细胞功能相关抗原-3/免疫球蛋白融合蛋白，淋巴细胞功能相关抗原-3 TIP，重组人淋巴细胞功能相关抗原-3/免疫球蛋白1融合蛋白，重组工程化人淋巴细胞功能相关抗原-1/免疫球蛋白1融合蛋白。
Drugs R D. 2002;3(1):21-4. doi: 10.2165/00126839-200203010-00004.
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Treatment of palmoplantar psoriasis with intramuscular alefacept.用肌肉注射阿法西普治疗掌跖银屑病。
J Am Acad Dermatol. 2005 Aug;53(2 Suppl 1):S127-9. doi: 10.1016/j.jaad.2004.12.024.
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New psoriasis treatments based upon a deeper understanding of the pathogenesis of psoriasis vulgaris and psoriatic arthritis: a personal appraisal of their use in practice.基于对寻常型银屑病和银屑病关节炎发病机制更深入理解的新型银屑病治疗方法：对其在实际应用中的个人评估。
J Am Acad Dermatol. 2003 Aug;49(2):351-6. doi: 10.1067/s0190-9622(03)01149-6.
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Alefacept therapy produces remission for patients with chronic plaque psoriasis.阿法西普疗法可使慢性斑块状银屑病患者病情缓解。
Br J Dermatol. 2003 Apr;148(4):784-8. doi: 10.1046/j.1365-2133.2003.05239.x.
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Possibilities of using alefacept in the treatment of psoriasis.使用阿法赛特治疗银屑病的可能性。
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):311-3.
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Safety and efficacy of alefacept, efalizumab, etanercept and infliximab in treating moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials.阿法赛特、依法利珠单抗、依那西普和英夫利昔单抗治疗中度至重度斑块状银屑病的安全性和有效性：一项随机对照试验的荟萃分析
Br J Dermatol. 2008 Aug;159(2):274-85. doi: 10.1111/j.1365-2133.2008.08673.x. Epub 2008 Jun 10.
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Alefacept in the treatment of psoriatic nail disease: a proof of concept study.阿法西普治疗银屑病甲病：一项概念验证研究。
J Drugs Dermatol. 2006 Apr;5(4):339-40.

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Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases.多态雌激素受体结合位点导致 Cd2 依赖性性别偏向与自身免疫性疾病易感性。
Nat Commun. 2021 Sep 22;12(1):5565. doi: 10.1038/s41467-021-25828-5.
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Adhesion molecules in cutaneous immunity.皮肤免疫中的黏附分子。
Semin Immunopathol. 2007 Apr;29(1):45-57. doi: 10.1007/s00281-007-0065-4.

本文引用的文献

1
Alefacept in the treatment of psoriatic nail disease: a small case series.阿法赛特治疗银屑病甲病：一项小病例系列研究。
J Am Acad Dermatol. 2005 Jun;52(6):1101-2. doi: 10.1016/j.jaad.2005.01.101.
2
Eruptive pseudoangiomatosis caused by an insect bite.由昆虫叮咬引起的发疹性假性血管瘤病。
J Am Acad Dermatol. 2005 Jan;52(1):174-5. doi: 10.1016/j.jaad.2004.07.051.
3
Remittive effects of intramuscular alefacept in psoriasis.肌肉注射阿法赛特治疗银屑病的缓解效果。
J Drugs Dermatol. 2003 Dec;2(6):624-8.
4
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study.接受阿法赛特治疗的银屑病患者中CD4 + T细胞定向抗体反应得以维持：一项随机研究的结果
J Am Acad Dermatol. 2003 Nov;49(5):816-25. doi: 10.1016/s0190-9622(03)01836-x.
5
An international, randomized, double-blind, placebo-controlled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis.一项针对慢性斑块型银屑病患者的肌肉注射阿法西普的国际、随机、双盲、安慰剂对照3期试验。
Arch Dermatol. 2003 Jun;139(6):719-27. doi: 10.1001/archderm.139.6.719.
6
Alefacept selectively promotes NK cell-mediated deletion of CD45R0+ human T cells.阿来西普可选择性地促进自然杀伤细胞介导的CD45R0+人T细胞的清除。
Eur J Immunol. 2003 Mar;33(3):666-75. doi: 10.1002/eji.200323586.
7
A randomized, double-blind, placebo-controlled phase III study evaluating efficacy and tolerability of 2 courses of alefacept in patients with chronic plaque psoriasis.一项评估两疗程阿法西普对慢性斑块状银屑病患者疗效和耐受性的随机、双盲、安慰剂对照III期研究。
J Am Acad Dermatol. 2002 Dec;47(6):821-33. doi: 10.1067/mjd.2002.127247.
8
Alefacept treatment in psoriatic arthritis: reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis.阿法赛特治疗银屑病关节炎：外周血和滑膜组织中效应T细胞数量的减少与关节炎临床症状的改善相关。
Arthritis Rheum. 2002 Oct;46(10):2776-84. doi: 10.1002/art.10543.
9
Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells.阿法赛特是一种免疫调节性重组LFA - 3/IgG1融合蛋白，可诱导CD16信号传导以及CD2(+)细胞的CD2/CD16依赖性凋亡。
J Immunol. 2002 May 1;168(9):4462-71. doi: 10.4049/jimmunol.168.9.4462.
10
Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.通过选择性靶向记忆效应T淋巴细胞治疗慢性斑块状银屑病。
N Engl J Med. 2001 Jul 26;345(4):248-55. doi: 10.1056/NEJM200107263450403.

用于治疗银屑病和银屑病关节炎的阿法西普。

Alefacept for psoriasis and psoriatic arthritis.

作者信息

Gottlieb A B

机构信息

Clinical Research Center, UMDNJ-Robert Wood Johnson Medical School, 51 French St., New Brunswick, NJ 08901-0019, USA.

出版信息

Ann Rheum Dis. 2005 Nov;64 Suppl 4(Suppl 4):iv58-60. doi: 10.1136/ard.2005.042655.

DOI:10.1136/ard.2005.042655
PMID:16239390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1766916/
Abstract

Alefacept is a bioengineered fusion protein of soluble lymphocyte function antigen (LFA-3) with Fc fragments of IgG1. It is marketed in many countries for the treatment of moderate to severe psoriasis. This paper reviews the data supporting the use of alefacept in psoriasis and psoriatic arthritis.

摘要

阿法赛特是一种生物工程融合蛋白，由可溶性淋巴细胞功能抗原（LFA-3）与IgG1的Fc片段组成。它在许多国家上市用于治疗中度至重度银屑病。本文综述了支持阿法赛特用于银屑病和银屑病关节炎的数据。