硫氧还蛋白-硫氧还蛋白还原酶系统前药抑制剂的合成及生物活性
Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system.
作者信息
Wipf Peter, Lynch Stephen M, Powis Garth, Birmingham Anne, Englund Erikah E
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
出版信息
Org Biomol Chem. 2005 Nov 7;3(21):3880-2. doi: 10.1039/b510718k. Epub 2005 Sep 28.
DOI:10.1039/b510718k
PMID:16240002
Abstract
A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile.
摘要
已合成了一系列棕榈霉素前药和水溶性类似物，并对其抑制硫氧还蛋白-硫氧还蛋白还原酶系统的能力进行了测定。水溶性的提高使体内活性谱得到改善。
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