Efremov V V
Genetika. 2005 Sep;41(9):1283-8.
Rates of approach to equilibrium values of F(ST)/R(ST) at various mutation rates and using different mutation models (K-allele model KAM and stepwise model SMM) were analyzed numerically for the finite island model and the one-dimensional stepping stone models of migration, using simulation. In the island model of migration and the KAM mutation model, the rate of approach to the equilibrium F(ST) value was appreciably higher and the equilibrium value was almost twofold lower at micro (mutation rate) = m (migration rate) than at micro << m. In the one-dimensional stepping stone model of migration and the KAM model of mutation, the mutation rate significantly affected both the rate of approaching F(ST) equilibrium and the equilibrium value. In both island and one-dimensional stepping stone models and SMM, R(ST) was not influenced by various mutation rates. The rate of approach to the equilibrium values of both F(ST) and R(ST) was lower for the stepping stone model than to the island model. RST was rather resistant to deviations from the SMM mutation model.
利用模拟方法，针对有限岛屿模型和一维 stepping stone 迁移模型，在不同突变率下并使用不同突变模型（K 等位基因模型 KAM 和逐步模型 SMM），对 F(ST)/R(ST)达到平衡值的速率进行了数值分析。在迁移的岛屿模型和 KAM 突变模型中，当微（突变率）= m（迁移率）时，达到平衡 F(ST)值的速率明显更高，且平衡值几乎比微 << m 时低两倍。在一维 stepping stone 迁移模型和 KAM 突变模型中，突变率对达到 F(ST)平衡的速率和平衡值均有显著影响。在岛屿模型和一维 stepping stone 模型以及 SMM 中，R(ST)不受各种突变率的影响。stepping stone 模型达到 F(ST)和 R(ST)平衡值的速率低于岛屿模型。RST 对偏离 SMM 突变模型具有相当的抗性。
