Blau Patricia A, Schwade Nathan, Roland Peter
Dept of Otorhinolaryngology, University of Texas Southwestern Medical Center at Dallas, TX 75390-8876, USA.
Ann Otol Rhinol Laryngol. 2005 Sep;114(9):722-9. doi: 10.1177/000348940511400912.
The purpose of this prospective study was to determine whether clinical doses of diazepam (DZ; 10 mg/d) administered for 14 days result in tolerance as measured by the sinuosidal harmonic acceleration (SHA) rotational test. It has been shown that repeated dosing with DZ leads to accumulation and tolerance in outcome measures that assess memory, sedation, and psychomotor tasks.
In a double-blinded, repeated-measures design, 30 normal male subjects who ranged in age from 20 to 36 years were randomly assigned to a placebo group or a DZ group and participated in 6 SHA rotational sessions over a 2-week period. Analysis of drug-placebo differences in percent change from baseline was performed with a 1-way analysis of variance.
Vestibulo-ocular reflex gain and phase frequencies at 0.01, 0.02, 0.04, and 0.08 Hz were significant (p < .05) for treatment group. No significant effect was observed for gain and phase frequency at 0.16 Hz--a finding that indicates selective effects on different central nervous system mechanisms. There was no statistical significance for time.
Clinically, the DZ subjects' scores remained within the normal ranges for vestibulo-ocular phase and gain, suggesting that patients in whom drug cessation is problematic may not have to discontinue DZ before testing with the SHA rotational system.
本前瞻性研究旨在确定连续14天给予临床剂量的地西泮（DZ；10毫克/天）是否会导致通过正弦谐波加速度（SHA）旋转试验所测量的耐受性。研究表明，重复给予DZ会导致在评估记忆、镇静和精神运动任务的结果指标中出现累积和耐受性。
采用双盲、重复测量设计，将30名年龄在20至36岁之间的正常男性受试者随机分为安慰剂组或DZ组，并在2周内参加6次SHA旋转试验。采用单因素方差分析对药物与安慰剂组从基线开始的百分比变化差异进行分析。
治疗组在0.01、0.02、0.04和0.08赫兹时的前庭眼反射增益和相位频率具有显著性（p < .05）。在0.16赫兹时未观察到增益和相位频率的显著影响——这一发现表明对不同中枢神经系统机制具有选择性作用。时间上无统计学意义。
临床上，DZ组受试者在前庭眼相位和增益方面的得分仍在正常范围内，这表明对于停药存在问题的患者，在使用SHA旋转系统进行测试之前可能无需停用DZ。
