急性胆汁淤积性肝炎可能与利培酮有关。
Acute cholestatic hepatitis probably associated with risperidone.
作者信息
Llinares Tello Francisca, Hernández Prats Carmen, Bosacoma Ros Nuria, Pérez Martínez Enrique, Climent Grana Eduardo, Navarro Polo José Noé, Ordovás Baines Juan Pablo
机构信息
Alicante University General Hospital, Spain.
出版信息
Int J Psychiatry Med. 2005;35(2):199-205. doi: 10.2190/5XRB-D2XX-X8AH-32KB.
OBJECTIVE
Risperidone is an atypical neuroleptic drug widely used due to the lower incidence and severity of hepatic adverse effects in comparison to phenothiazines. Although idiosyncratic reversible hepatotoxicity may occur in association with risperidone, the interaction with fluoxetine might increase the risk of toxic liver injury in a vulnerable patient.
METHODS AND RESULTS
We present a case of acute cholestatic hepatitis probably associated with the use of risperidone after only a few days of therapy in a patient also treated with fluoxetine. The patient, a 64-year-old male, developed a rapid increase in liver enzymes after starting treatment with only four doses of risperidone 2 mg/day.
CONCLUSIONS
We recommend obtaining baseline liver function tests before starting risperidone and regular monitoring to screen patients for liver damage during therapy whenever a patient is also receiving fluoxetine.
目的
利培酮是一种非典型抗精神病药物，与吩噻嗪类药物相比，因其肝脏不良反应的发生率和严重程度较低而被广泛使用。尽管利培酮可能会发生特发性可逆性肝毒性，但与氟西汀的相互作用可能会增加易损患者发生中毒性肝损伤的风险。
方法与结果
我们报告一例急性胆汁淤积性肝炎病例，该病例可能与一名同时接受氟西汀治疗的患者在使用利培酮仅几天后有关。该患者为一名64岁男性，在开始每天服用4剂2毫克利培酮治疗后，肝酶迅速升高。
结论
我们建议在开始使用利培酮前进行基线肝功能检查，并在患者同时接受氟西汀治疗时，在治疗期间定期监测以筛查肝脏损伤。
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