Sweeney K J, Weiss A S
Department of Biochemistry, University of Sydney, NSW, Australia.
Gerontology. 1992;38(3):139-52. doi: 10.1159/000213321.
Hyaluronic acid (HA) is implicated in functions such as vascularity, morphogenesis, repair, and the general integrity of the extracellular matrix. Hence, it is considered possible that HA is involved in the most conspicuous features of the progeroid phenotype. However, it is not known whether the increase in HA excretion seen in progeria patients is due to a primary genetic defect or is a secondary effect due to some deeper problem. The phenomenon of 'normal' aging is suggested to have a more complex etiology and phenotype than progeria and the role of HA levels is less well-defined.
透明质酸（HA）与血管生成、形态发生、修复以及细胞外基质的整体完整性等功能有关。因此，HA有可能参与了早老性表型的最显著特征。然而，早衰症患者中观察到的HA排泄增加是由于原发性基因缺陷，还是由于某些更深层次问题导致的继发性效应，目前尚不清楚。与早衰症相比，“正常”衰老现象的病因和表型更为复杂，HA水平的作用也不太明确。
