Menzel E J, Smolen J S, Kojer M
Acta Med Austriaca Suppl. 1979;6:399-401.
Acetylation of insulin with 3H-acetic anhydride resulted in the predominant 3H-labeling at the aminoterminal position of the B-chain (B1). The labeled insulin was unchanged in its immunologic reactivity as compared to native insulin. It was used in a second antibody radioimmunoassay for the detection of antiinsulin-antibodies in insulin-dependent patients with Diabetes mellitus.
用³H-乙酸酐对胰岛素进行乙酰化反应，结果显示³H主要标记在B链的氨基末端位置（B1）。与天然胰岛素相比，标记后的胰岛素免疫反应性未发生改变。它被用于一种第二抗体放射免疫测定法，以检测胰岛素依赖型糖尿病患者体内的抗胰岛素抗体。
