自然观看条件下集合的年龄相关性变化。

Age-related changes of vergence under natural viewing conditions.

作者信息

Rambold Holger, Neumann Gunnar, Sander Thurid, Helmchen Christoph

机构信息

Department of Neurology, University of Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany.

出版信息

Neurobiol Aging. 2006 Jan;27(1):163-72. doi: 10.1016/j.neurobiolaging.2005.01.002.

DOI:10.1016/j.neurobiolaging.2005.01.002

PMID:16243410

Abstract

Vergence eye movements were recorded with the scleral search-coil system in 32 healthy subjects (ages 19-73 years) to characterize the age-related effects on the dynamic parameters of vergence responses to step (transient components) and ramp or sinusoidal targets (sustained components) under natural viewing conditions. Transient vergence showed an age-related increase in latency and decreases in peak velocity and acceleration in the binocular stimulus condition but not in accommodative vergence. Sustained vergence showed no age-related effect in the binocular condition, but there was an age-related decrease in accommodative vergence steady-state velocity and an increase in latency. Age-related changes of the transient and sustained components were very similar to those reported for saccades and smooth pursuit; they thus might support a distinction between a sustained and transient vergence system. Furthermore, such age-related effects have to be taken into account when assessing eye movement disorders in neurodegenerative and cerebrovascular diseases.

摘要

在32名健康受试者（年龄19 - 73岁）中，使用巩膜搜索线圈系统记录了聚散眼球运动，以表征在自然观察条件下，年龄对聚散反应动态参数（对阶跃目标（瞬态成分）以及斜坡或正弦目标（持续成分））的影响。在双眼刺激条件下，瞬态聚散表现出与年龄相关的潜伏期增加、峰值速度和加速度降低，但在调节性聚散中未出现这种情况。在双眼条件下，持续聚散未表现出与年龄相关的影响，但调节性聚散的稳态速度出现与年龄相关的降低，潜伏期增加。瞬态和持续成分的年龄相关变化与扫视和平滑跟踪所报道的变化非常相似；因此，它们可能支持区分持续聚散系统和瞬态聚散系统。此外，在评估神经退行性疾病和脑血管疾病中的眼球运动障碍时，必须考虑这种与年龄相关的影响。