Sunila E S, Kuttan G
Amala Cancer Research Centre, Trissur, India.
Fitoterapia. 2005 Dec;76(7-8):649-55. doi: 10.1016/j.fitote.2005.08.008. Epub 2005 Oct 21.
The radioprotective property of an ethanolic extract of Piper longum fruits (EEPLF) was investigated in Swiss mice. The white blood cell (WBC) count in irradiated control mice was drastically reduced to 1900 cells/mm3 on third day but in treated animals the count was 2783.3 cells/mm3. The number of bone marrow cells and alpha-esterase positive cells was also enhanced by the EEPLF administration (16.7 x 10(6) cells/femur and 946.5/4000 cells, respectively) when compared to the radiation exposed control animals (12.2 x 10(6) cells/femur and 693.5/4000 cells, respectively). EEPLF reduced the elevated levels of glutathione pyruvate transaminase (GPT), alkaline phosphatase (ALP), and lipid peroxidation (LPO) in liver and serum of radiation treated animals. The extract administration also increased the reduced glutathione (GSH) production to offer the radioprotection.
在瑞士小鼠中研究了荜茇果实乙醇提取物（EEPLF）的辐射防护特性。照射后对照组小鼠的白细胞（WBC）计数在第三天急剧降至1900个细胞/mm³，但在经处理的动物中，计数为2783.3个细胞/mm³。与接受辐射的对照动物（分别为12.2×10⁶个细胞/股骨和693.5/4000个细胞）相比，给予EEPLF后骨髓细胞和α-酯酶阳性细胞的数量也有所增加（分别为16.7×10⁶个细胞/股骨和946.5/4000个细胞）。EEPLF降低了辐射处理动物肝脏和血清中谷胱甘肽丙酮酸转氨酶（GPT）、碱性磷酸酶（ALP）和脂质过氧化（LPO）的升高水平。提取物的给予还增加了还原型谷胱甘肽（GSH）的产生以提供辐射防护。
