Loffeld R J L F
Department of Internal Medicine, Zaans Medical Centre, PO Box 210, 1500 EE Zaandam, the Netherlands.
Neth J Med. 2005 Oct;63(9):344-7.
The incidence and prevalence of gastro-oesophageal reflux disease is rising. Changing dietary habits and increasing body weight can be held responsible. In several studies a close relation was found between body weight and the occurrence of reflux disease. It may be concluded that there is a definite relation between body mass index and the occurrence of reflux disease. H. pylori probably also plays a role. H. pylori causes changes in fundic leptin levels and plasma levels of ghrelin. Eradication of H. pylori infection can increase appetite leading to a rise in body mass index due to a higher caloric intake. H. pylori can be a 'protective' factor against the development of overweight. Since only a minority of overweight or obese patients with gastro-oesophageal reflux disease will lose weight successfully, medical treatment with effective acid suppression will be the mainstay of the treatment of reflux disease in patients with a high body mass index.
胃食管反流病的发病率和患病率正在上升。饮食习惯的改变和体重增加难辞其咎。在多项研究中，人们发现体重与反流病的发生之间存在密切关系。可以得出结论，体重指数与反流病的发生之间存在明确的关联。幽门螺杆菌可能也起到了一定作用。幽门螺杆菌会导致胃底瘦素水平和胃饥饿素血浆水平发生变化。根除幽门螺杆菌感染会增加食欲，由于热量摄入增加导致体重指数上升。幽门螺杆菌可能是预防超重发生的一个“保护”因素。由于只有少数患有胃食管反流病的超重或肥胖患者能够成功减重，因此对于体重指数较高的反流病患者，有效的抑酸药物治疗将是主要的治疗方法。
