秀丽隐杆线虫突变体中寿命与百草枯抗性的解偶联
Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.
作者信息
Fujii Michihiko, Tanaka Nanae, Miki Kensuke, Hossain Mohammad Nazir, Endoh Morio, Ayusawa Dai
机构信息
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Japan.
出版信息
Biosci Biotechnol Biochem. 2005 Oct;69(10):2015-8. doi: 10.1271/bbb.69.2015.
To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 degrees C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.
为了分析抗氧化应激能力与寿命之间的关系，我们从秀丽隐杆线虫中分离出了三个新的百草枯抗性突变体，即mev-5、mev-6和mev-7。它们均表现出Dyf（染料填充缺陷）表型，但并非总是耐热或耐紫外线。仅在26摄氏度下观察到mev-5突变体的寿命延长。这些结果表明，寿命与百草枯抗性表型无关。
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