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什么是基因专利,为什么人们对此感到担忧?

What are gene patents and why are people worried about them?

作者信息

Merz Jon F, Cho Mildred K

机构信息

Department of Medical Ethics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-3308, USA.

出版信息

Community Genet. 2005;8(4):203-8. doi: 10.1159/000087956.

DOI:10.1159/000087956
PMID:16244473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2220018/
Abstract

This article examines what it means to patent a gene. Numerous ethical concerns have been raised about the effects of such patents on clinical medical practice as well as on research and development. We describe what kinds of inventions are covered by human gene patents, give several examples and summarize the small body of empirical research performed in the US examining the effects of these patents. There is little evidence that early fears about gene patenting placing substantial restraints on research and clinical medicine have come to fruition. Nonetheless, there are areas of concern, and policy makers, physicians and the public should be alert to ensure that the net social benefits of patenting human genes are maintained.

摘要

本文探讨了为基因申请专利意味着什么。关于此类专利对临床医学实践以及研发的影响,人们提出了诸多伦理方面的担忧。我们描述了人类基因专利涵盖的发明类型,给出了几个例子,并总结了美国进行的少量实证研究,这些研究考察了这些专利的影响。几乎没有证据表明,早期对基因专利会给研究和临床医学带来重大限制的担忧已经成为现实。尽管如此,仍存在一些令人担忧的领域,政策制定者、医生和公众应保持警惕,以确保人类基因专利的社会净效益得以维持。

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1
What are gene patents and why are people worried about them?什么是基因专利,为什么人们对此感到担忧?
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2
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Patents, medicine, and the interests of patients: applying general principles to gene patenting.专利、药品与患者利益:将一般原则应用于基因专利
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Gene patents: a broken incentives system.基因专利:一个有缺陷的激励体系。
J Relig Health. 2013 Dec;52(4):1079-84. doi: 10.1007/s10943-013-9758-2.
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Gene patents and personalized cancer care: impact of the Myriad case on clinical oncology.基因专利与个体化癌症治疗:Myriad 案对临床肿瘤学的影响。
J Clin Oncol. 2013 Jul 20;31(21):2743-8. doi: 10.1200/JCO.2013.49.7388. Epub 2013 Jun 13.
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Integrating stakeholder perspectives into the translation of cell-free fetal DNA testing for aneuploidy.将利益相关者观点纳入游离胎儿 DNA 检测非整倍体的翻译中。
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It's about scientific secrecy, dummy: a better equilibrium among genomics patenting, scientific research and health care.这是关于科学保密的问题,蠢货:在基因组专利、科学研究和医疗保健之间取得更好的平衡。
Sci Eng Ethics. 2012 Jun;18(2):263-84. doi: 10.1007/s11948-011-9257-3. Epub 2011 Feb 13.

本文引用的文献

1
The patent is political: the consequences of patenting the BRCA genes in Britain.
Community Genet. 2005;8(4):235-42. doi: 10.1159/000087961.
2
Balancing innovation and access to healthcare through the patent system--an Australian perspective.通过专利制度平衡医疗创新与可及性——澳大利亚视角
Community Genet. 2005;8(4):228-34. doi: 10.1159/000087960.
3
A pilot survey on the licensing of DNA inventions.关于DNA发明许可的初步调查。
J Law Med Ethics. 2003 Fall;31(3):442-9. doi: 10.1111/j.1748-720x.2003.tb00107.x.
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Science and the law. Working through the patent problem.科学与法律。解决专利问题。
Science. 2003 Feb 14;299(5609):1021. doi: 10.1126/science.299.5609.1021.
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Patents and innovation in cancer therapeutics: lessons from CellPro.癌症治疗领域的专利与创新:来自赛尔普罗公司的经验教训
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Genetics. DNA patenting and licensing.遗传学。DNA专利与许可。
Science. 2002 Aug 23;297(5585):1279. doi: 10.1126/science.1070899.
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Gene patents and the standard of care.基因专利与医疗标准。
CMAJ. 2002 Aug 6;167(3):256-7.
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Diagnostic testing fails the test.诊断测试未通过测试。
Nature. 2002 Feb 7;415(6872):577-9. doi: 10.1038/415577a.