Manieri C, Pastorino R, Marolda A R, Musso M C, Gellona A, Barberis A, Boggio G, Messina M
Dipartimento di Fisiopatologia Clinica, Divisione Universitaria di Endocrinologia, Torino, Italy.
J Endocrinol Invest. 1992 Mar;15(3):219-22. doi: 10.1007/BF03348715.
The LH/FSH ratio values between gonadotropins dosed with a monoclonal antibody assay (IRMA) in the micropolycystic ovary syndrome (PCOS), are discussed and compared to those obtained with the classic assays using polyclonal antibodies. Because of the higher selectivity of this IRMA assay it is noteworthy that the cut-off value between normal and PCOS patients is now equal to or above one. The evaluation of the LH/FSH ratio between the peak values of the two gonadotropins after a GnRH 100 micrograms iv bolus, may be useful in the diagnosis of PCOS in those patients who present an LH/FSH less than 1 in basal conditions even in the presence of clinical and ecographic aspects of PCOS.
讨论了多囊卵巢综合征（PCOS）患者使用单克隆抗体测定法（免疫放射分析，IRMA）测定促性腺激素时的LH/FSH比值，并与使用多克隆抗体的经典测定法所获得的比值进行比较。由于这种IRMA测定法具有更高的选择性，值得注意的是，正常患者与PCOS患者之间的临界值现在等于或高于1。对于基础状态下LH/FSH小于1但存在PCOS临床和超声表现的患者，静脉注射100微克促性腺激素释放激素（GnRH）推注后两种促性腺激素峰值之间的LH/FSH比值评估，可能有助于PCOS的诊断。
