Alper R H
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center.
J Gerontol. 1992 Jul;47(4):B130-6. doi: 10.1093/geronj/47.4.b130.
Male F344BNF1 hybrid rats (F1 crosses between female Fischer 344 and male Brown Norway rats) aged 3 or 24 months were treated with vehicle (1 ml water/kg, IP) or fluoxetine (10 mg/kg, IP) once a day for 1 day or 27 consecutive days; body weights were recorded daily. Baroreceptor sensitivity was assessed in conscious unrestrained rats implanted with vascular catheters 24 hours after the single or 27th injection by measuring peak changes in mean arterial pressure (MAP) and heart rate (HR) elicited by graded doses of phenylephrine or nitroglycerin, IV. The results demonstrate that the effects of the serotonin uptake inhibitor fluoxetine, whether administered acutely or for 27 days, are similar in young and old rats: a relative decrease in body weight, a slight decrease in resting MAP without a change in HR, and no effect on baroreceptor sensitivity. In addition, this study in F344BNF1 hybrid rats supports previous reports in inbred rat strains by demonstrating that baroreceptor dysfunction, but not hypertension, is observed in old rats.
3个月或24个月大的雄性F344BNF1杂交大鼠（雌性Fischer 344大鼠与雄性Brown Norway大鼠的F1代杂交后代），每天接受一次载体（1毫升水/千克，腹腔注射）或氟西汀（10毫克/千克，腹腔注射）治疗，持续1天或连续27天；每天记录体重。在单次或第27次注射24小时后，通过测量静脉注射不同剂量去氧肾上腺素或硝酸甘油引起的平均动脉压（MAP）和心率（HR）的峰值变化，评估植入血管导管的清醒无束缚大鼠的压力感受器敏感性。结果表明，血清素摄取抑制剂氟西汀无论是急性给药还是给药27天，对年轻和老年大鼠的作用相似：体重相对下降，静息MAP略有下降，HR无变化，对压力感受器敏感性无影响。此外，这项在F344BNF1杂交大鼠中的研究通过证明老年大鼠存在压力感受器功能障碍而非高血压，支持了之前在近交系大鼠中的报道。
