Conti G
Unità Operativa di Urologia, Ospedale Sant'Anna, Como, Italy.
Minerva Urol Nefrol. 2005 Dec;57(4):313-7.
Zoledronic acid is the most biologically active of all bisphosphonates. Clinical evidence suggests that it acts not only on osteoclasts and bone resorption but that it also displays antitumoral activity, proaptotic activity in synergy with antineoplastic drugs and antiangiogenic activity. Moreover, studies on zoledronic acid have reported that the agent is the only biphosphonate of demonstrated efficacy (vs. placebo) in the treatment of prostate cancer, both at a late stage of disease following bone metastasis (over 5-month delay of first skeletal event and 36% reduction in global risk of skeletal complications) and at bone demineralization in subjects receiving androgenic depletion (overall improvement of 8% in bone mineral density).
唑来膦酸是所有双膦酸盐中生物活性最强的。临床证据表明，它不仅作用于破骨细胞和骨吸收，还具有抗肿瘤活性、与抗肿瘤药物协同的促凋亡活性和抗血管生成活性。此外，关于唑来膦酸的研究报告称，该药物是唯一在治疗前列腺癌方面显示出疗效（与安慰剂相比）的双膦酸盐，无论是在骨转移后的疾病晚期（首次骨骼事件延迟超过5个月，骨骼并发症总体风险降低36%），还是在接受雄激素剥夺治疗的受试者的骨质脱矿方面（骨矿物质密度总体提高8%）。
