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Synthesis of carbocyclic nucleotides as potential substrates for thymidylate kinase.

作者信息

Ludek O R, Meier C

机构信息

Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, Hamburg D-20146, Germany.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):683-6. doi: 10.1081/ncn-200060251.

DOI:10.1081/ncn-200060251
PMID:16248014
Abstract

Enantiomerically pure carbocyclic 2'-deoxy-3'-azidothymidine monophosphate (AZTMP) and carba-2'deoxy-3'-thiocyanatothymidine monophosphate were synthesized to study their behavior toward their phosphorylation by thymidylate kinase. The nucleotides were synthesized starting from the parent nucleosides by an alkaline hydrolysis of the corresponding cycloSal-phosphate triesters.

摘要

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