芳基核苷H-膦酸酯作为研究偶联过程中立体特异性的工具。
Aryl nucleoside H-phosphonates as a tool for investigation of stereospecificity during coupling.
作者信息
Sobkowski Michal, Jankowska Jadwiga, Stawinski Jacek, Kraszewski Adam
机构信息
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14 61-704, Poznan, Poland.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):887-90. doi: 10.1081/ncn-200059239.
PMID:16248055
Abstract
It was found that in stereoselective condensations of ribonucleoside 3'-H-phosphonates with alcohols, the major diastereomer of the produced H-phosphonate diesters is formed from the minor diastereomer of the intermediate phosphonic-pivalic anhydride.
摘要
研究发现，在核糖核苷3'-H-膦酸酯与醇的立体选择性缩合反应中，生成的H-膦酸二酯的主要非对映异构体是由中间体膦酰-新戊酸酐的次要非对映异构体形成的。
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