Ryan Maria Emanuel
Stony Brook University, School of Dental Medicine, Department of Oral Biology and Pathology, South Campus, Stony Brook, NY 11794, USA.
J Int Acad Periodontol. 2005 Oct;7(4 Suppl):162-71; discussion 172-4.
Attachment levels are excellent indicators of past destruction of the periodontal attachment apparatus and can be used to monitor the progression of periodontitis. They have been used in clinical trials to monitor the efficacy of a variety of therapeutic modalities that may either slow the progression of periodontal disease or allow for regeneration of lost attachment and supporting structures. Inherent difficulties in accurately assessing attachment levels include inflammation, which causes coronal displacement of the gingival margin without a concomitant migration of the dentogingival epithelium to a level apical to the cementoenamel junction, and recessions, in which an obvious loss of attachment has occurred, but there is no increase in probing depth. Attachment level measurements are more frequently used as clinical end-points in clinical trials than by private practitioners to determine the periodontal status of patients and to monitor patient responses to periodontal therapy. Clinical attachment level measurements have been used in clinical trials to evaluate a systemic host modulatory agent, demonstrating their utility as surrogate markers of efficacy.
附着水平是牙周附着装置既往破坏情况的极佳指标，可用于监测牙周炎的进展。它们已被用于临床试验，以监测各种治疗方式的疗效，这些治疗方式可能会减缓牙周疾病的进展，或促进丧失的附着及支持结构的再生。准确评估附着水平存在一些内在困难，包括炎症，炎症会导致牙龈边缘向冠方移位，而龈牙上皮并未随之向釉牙骨质界根尖方水平迁移；以及牙龈退缩，即出现明显的附着丧失，但探诊深度并无增加。在临床试验中，附着水平测量作为临床终点指标的使用频率高于私人执业医生用于确定患者牙周状况及监测患者对牙周治疗反应的频率。临床附着水平测量已在临床试验中用于评估一种全身宿主调节因子，证明了其作为疗效替代标志物的效用。
