Ono Kenichiro, Shirotani Toshiki, Yuba Koji, Yamana Daigo
Department of Neurosurgery, Japan Self Defense Force Central Hospital, 1-2-24 Ikejiri, Setagayaku, Tokyo 154-8532, Japan.
No To Shinkei. 2005 Sep;57(9):779-84.
Using CT perfusion studies we evaluated changes in the cerebral circulation before and after the intravenous administration of fasudil 60 mg in 8 patients 7 to 14 days after a subarachnoid hemorrhage. The mean duration to the peak of the time-density curve and the average peak value did not change. In areas with cerebral blood perfusion (CBP) less than 40 ml/100 g/min, the CBP increased from 34.4 +/- 4.7 ml/100 g/min to 41.0 +/- 8.2 ml/100 g/min (p < 0.01) after fasudil infusion, the cerebral blood volume (CBV) rose from 2.41 +/- 0.53 ml/100 g to 2.55 +/- 0.5 ml/100 g (p < 0.05), and the mean transit time (MTT) decreased from 5.09 +/- 1.13 s to 4.82 +/- 0.89 s (p < 0.05). In areas where the CBP was more than 41 ml/100 g/min, the CBP did not change (from 51.8 +/- 7.6 ml/100 g/min to 50.4 +/- 8.4 ml/100 g/min), the CBV decreased (from 2.75 +/- 0.62 ml/100 g to 2.67 +/- 0.55 ml/100 g, p < 0.05), and the MTT did not change (from 3.80 +/- 0.76 s to 3.77 +/- 0.72 s). These results suggest that intravenous infusion of fasudil 60 mg increases cerebral blood flow and cerebral blood volume and shortens MTT in areas with decreased blood flow due to vasospasm.
我们采用CT灌注研究评估了8例蛛网膜下腔出血后7至14天的患者静脉注射60毫克法舒地尔后脑循环的变化。时间-密度曲线峰值的平均持续时间和平均峰值未发生改变。在脑血流灌注（CBP）小于40毫升/100克/分钟的区域，法舒地尔输注后CBP从34.4±4.7毫升/100克/分钟增加至41.0±8.2毫升/100克/分钟（p<0.01），脑血容量（CBV）从2.41±0.53毫升/100克增加至2.55±0.5毫升/100克（p<0.05），平均通过时间（MTT）从5.09±1.13秒降至4.82±0.89秒（p<0.05）。在CBP大于41毫升/100克/分钟的区域，CBP未改变（从51.8±7.6毫升/100克/分钟至50.4±8.4毫升/100克/分钟），CBV降低（从2.75±0.62毫升/100克至2.67±0.55毫升/100克，p<0.05），MTT未改变（从3.80±0.76秒至3.77±0.72秒）。这些结果表明，静脉输注60毫克法舒地尔可增加因血管痉挛导致血流减少区域的脑血流量和脑血容量，并缩短MTT。
