Loesch Andrzej
Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, University College London, UK.
Curr Vasc Pharmacol. 2005 Oct;3(4):381-92. doi: 10.2174/157016105774329381.
Since the discovery of endothelin in vascular endothelial cells and its pivotal role in vascular physiology (Yanagisawa and colleagues), a number of studies have focused on the localisation of this vasoconstrictor peptide in human and animal vascular tissue, largely in endothelial cells. Various vascular beds have been the subject of research in normal and pathophysiological conditions, for example in neonates, during ageing, pregnancy, hypertension, diabetes, heart failure, experimental metastases and neurological disorders. These studies have revealed the presence of endothelin in the blood vessel wall, suggesting the involvement of this peptide in vascular physiology in health and disease. This chapter reviews studies on the distribution of endothelin-1 (ET-1) and its receptors (ET(A) and ET(B)) in vascular tissue with emphasis on their ultrastructural localisation.
自从在血管内皮细胞中发现内皮素及其在血管生理学中的关键作用（柳泽及其同事）以来，许多研究聚焦于这种血管收缩肽在人和动物血管组织中的定位，主要是在内皮细胞中。各种血管床已成为正常和病理生理条件下的研究对象，例如在新生儿、衰老、妊娠、高血压、糖尿病、心力衰竭、实验性转移和神经疾病期间。这些研究揭示了血管壁中存在内皮素，表明该肽参与了健康和疾病状态下的血管生理过程。本章综述了关于内皮素-1（ET-1）及其受体（ET(A)和ET(B)）在血管组织中的分布研究，重点是它们的超微结构定位。
