Lee Na Kyung, Lee Soo Young
Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Seoul 120-750, Korea.
J Biochem Mol Biol. 2002 Jan 31;35(1):61-6. doi: 10.5483/bmbrep.2002.35.1.061.
The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-kappaB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.
肿瘤坏死因子受体相关因子（TRAF）家族是一组衔接蛋白，可连接多种细胞表面受体，包括肿瘤坏死因子和白细胞介素-1受体超家族，使其与不同的信号级联反应相连，进而导致核因子κB和丝裂原活化蛋白激酶的激活。此外，TRAFs与多种调节受体诱导的细胞死亡或存活的蛋白质相互作用。因此，TRAF介导的信号可能直接诱导细胞存活或干扰死亡受体诱导的细胞凋亡。
