Martin Brent J, Suckow Mark A, Wolter William R, Berger Thomas, Turner John W
Division of Laboratory Animal Medicine, Medical University of Ohio, 3055 Arlington Avenue, Toledo, OH 43614, USA.
Anim Reprod Sci. 2006 Jul;93(3-4):372-8. doi: 10.1016/j.anireprosci.2005.09.007. Epub 2005 Oct 24.
Rabbits (Oryctolagus cuniculus) and two strains of mice (Mus musculus, one inbred and one outbred) were immunized against porcine zona pellucida (PZP) antigen. Alginate microspheres or cholera toxin B were used alone or in combination when mucosal immunization routes were used. Serum antibody responses and fertility were assessed. Neither rabbit or mouse groups immunized by mucosal routes generated significant antibody responses to PZP as compared to parenteral immunization (ANOVA, P > 0.05). The study shows that porcine zona pellucida is not an effective mucosal antigen in small mammals.
用猪透明带（PZP）抗原对家兔（穴兔）和两种品系的小鼠（小家鼠，一种是近交系，一种是远交系）进行免疫。当采用黏膜免疫途径时，单独或联合使用藻酸盐微球或霍乱毒素B。评估血清抗体反应和生育能力。与经肠外免疫相比，通过黏膜途径免疫的家兔或小鼠组均未对PZP产生显著的抗体反应（方差分析，P>0.05）。该研究表明，猪透明带在小型哺乳动物中不是一种有效的黏膜抗原。
