Wang Yi-Shi, Tay Yong-Kwang, Tan Eileen, Poh Wee-Teng
Division of Dermatology, Department of Laboratory Medicine, Changi General Hospital, Singapore.
J Dermatolog Treat. 2005;16(4):242-4. doi: 10.1080/09546630510044003.
Kimura's disease is a rare, chronic inflammatory disease of unknown cause. It is characterized by painless subcutaneous swellings and lymphadenopathy, commonly affecting the head and neck region. This is associated with peripheral blood eosinophilia and raised serum IgE. It has distinct histological features of lymphoid follicles, eosinophilic infiltrate, fibrosis and vascular proliferation. The disease usually has a benign, indolent course. Traditionally, therapeutic options have included surgery, radiotherapy and steroids but response has been less than satisfactory. Recently, cyclosporine has been reported to be effective in the treatment of Kimura's disease. In this article, we present a middle-aged Chinese female with Kimura's disease for 20 years and her favourable response to cyclosporine.
木村病是一种病因不明的罕见慢性炎症性疾病。其特征为无痛性皮下肿胀和淋巴结病，常见于头颈部区域。这与外周血嗜酸性粒细胞增多和血清IgE升高有关。它具有淋巴滤泡、嗜酸性粒细胞浸润、纤维化和血管增生等独特的组织学特征。该疾病通常呈良性、惰性病程。传统上，治疗选择包括手术、放疗和类固醇，但疗效并不理想。最近，有报道称环孢素对木村病的治疗有效。在本文中，我们介绍了一位患有木村病20年的中国中年女性以及她对环孢素的良好反应。
