Klausner J D, Sweeney J A, Deck M D, Haas G L, Kelly A B
Cornell University Medical College, New York, New York.
J Nerv Ment Dis. 1992 Jul;180(7):407-12. doi: 10.1097/00005053-199207000-00001.
Numerous studies have shown evidence of cerebral ventricular enlargement in schizophrenia and its relationship to severity of clinical symptoms and psychosocial dysfunction. In this large prospective study, 88 noninstitutionalized DSM-III-R schizophrenic patients were administered a CT scan and rated for positive and negative symptomatology and premorbid adjustment. The CT scans from 14 healthy controls were used for comparison of cerebral ventricular measures. Patients had an enlarged ventricle to brain ratio of the anterior portion of the lateral ventricles, the frontal horns, compared with controls. Patients with larger frontal horns had more severe negative symptoms and poorer premorbid childhood adjustment. The area of the main body of the cerebral lateral ventricles, though not elevated in patients, was correlated with the total number of prior hospitalizations. These results support the hypothesis of a structural and functional "frontal" deficit in schizophrenia.
众多研究已证实精神分裂症患者存在脑室扩大现象，及其与临床症状严重程度和心理社会功能障碍的关系。在这项大型前瞻性研究中，对88名非住院的DSM-III-R精神分裂症患者进行了CT扫描，并对其阳性和阴性症状及病前适应情况进行了评分。将14名健康对照者的CT扫描结果用于脑室测量的比较。与对照组相比，患者侧脑室前部（额角）的脑室与脑比例增大。额角较大的患者有更严重的阴性症状，病前儿童期适应情况更差。尽管患者大脑侧脑室主体区域未升高，但与既往住院总次数相关。这些结果支持了精神分裂症存在结构性和功能性“额叶”缺陷的假说。
