Sun Guang, Vasdev Sudesh, Martin Glynn R, Gadag Veeresh, Zhang Hongwei
Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
Diabetes. 2005 Nov;54(11):3336-9. doi: 10.2337/diabetes.54.11.3336.
Alteration of extracellular calcium concentration may be involved in glucose metabolism in a number of pathways. The present study was designed to investigate the relationship between total serum calcium and 1) fasting serum glucose, 2) insulin, 3) insulin resistance, and 4) beta-cell function in 1,182 healthy subjects from the province of Newfoundland and Labrador, Canada. All variables were log10 transformed, and confounding factors including age, trunk fat percentage, serum phosphorus, magnesium, 25-OH vitamin D, and parathyroid hormone were adjusted before analyses. Significant positive correlations between glucose and insulin resistance with calcium were found in both sexes, whereas an inverse correlation between beta-cell function and calcium was found only in women. Similar results were found in medication-free women and men, as well as in pre- and postmenopausal women. Subjects with low calcium levels had the lowest concentration of glucose and the least insulin resistance, whereas subjects with high calcium levels had the highest concentration of glucose and insulin resistance in women but not in men. This relationship remained after calcium was adjusted for 25-OH vitamin D and parathyroid hormone. Our results suggest that alteration of serum calcium homeostasis is significantly correlated with the abnormality of glucose level, insulin resistance, and beta-cell function.
细胞外钙浓度的改变可能通过多种途径参与葡萄糖代谢。本研究旨在调查加拿大纽芬兰和拉布拉多省1182名健康受试者的血清总钙与以下因素之间的关系：1）空腹血糖；2）胰岛素；3）胰岛素抵抗；4）β细胞功能。所有变量均进行log10转换，并在分析前对包括年龄、躯干脂肪百分比、血清磷、镁、25-羟基维生素D和甲状旁腺激素在内的混杂因素进行了调整。在男女两性中均发现葡萄糖和胰岛素抵抗与钙之间存在显著正相关，而仅在女性中发现β细胞功能与钙之间存在负相关。在未服用药物的男性和女性以及绝经前和绝经后女性中也发现了类似结果。钙水平低的女性受试者血糖浓度最低，胰岛素抵抗最小，而钙水平高的女性受试者血糖浓度和胰岛素抵抗最高，但男性并非如此。在对25-羟基维生素D和甲状旁腺激素进行钙校正后，这种关系仍然存在。我们的结果表明血清钙稳态的改变与血糖水平、胰岛素抵抗和β细胞功能异常显著相关。
