Odink Roelof J, Gerver Willem Jan, Heeg Minne, Rouwé Catrienus W, van Waarde Willie M Bakker, Sauer Pieter J
Department of Paediatrics, Division of Endocrinology, Beatrix Children's Hospital, Hanzeplein 1, 9713 GZ , Groningen, The Netherlands.
Eur J Pediatr. 2006 Jan;165(1):50-4. doi: 10.1007/s00431-005-1722-z. Epub 2005 Oct 26.
In this study, the results of percutaneous epiphysiodesis as a surgical method to decrease final height is described in 15 boys with a predicted final height of more than 205 cm. A total of 17 boys with a height prediction between 195 and 209 cm without treatment were included as controls. The study period was from 1995-2002 and patients were followed for a mean period of 3.9 years (range 2.3-6.5 years) after surgery; controls were followed for 8.3 years (range 2.0-12.1 years). Final height in the treated boys was 203.6 cm (range 195.5-214.5 cm) compared to the predicted height of 210.6 cm (range 205.7-222.7 cm). The reduction in final height versus the predicted height was 7 cm and ranged between 1.2 and 13.8 cm. Final height in the control boys was 199.9 cm (range 191.3-206.7 cm). No significant side-effects of epiphysiodesis were observed. Besides final height reduction, epiphysiodesis resulted in normalisation of body proportions, expressed as the subischial leg length/sitting height ratio. This ratio in the operated patients at final height was 0.96 (range 0.90-1.01) and in the controls 0.94 (range 0.88-1.03).
Epiphysiodesis can be advised as a method to decrease final height in boys with predicted tall stature. An additional advantage of this method is a normalisation of body proportions.
在本研究中,描述了经皮骨骺阻滞术作为一种降低最终身高的手术方法在15名预计最终身高超过205厘米的男孩中的应用结果。总共纳入了17名未经治疗、身高预测在195至209厘米之间的男孩作为对照。研究时间段为1995年至2002年,术后对患者平均随访3.9年(范围2.3至6.5年);对对照随访8.3年(范围2.0至12.1年)。接受治疗的男孩最终身高为203.6厘米(范围195.5至214.5厘米),而预测身高为210.6厘米(范围205.7至222.7厘米)。最终身高相对于预测身高降低了7厘米,范围在1.2至13.8厘米之间。对照男孩的最终身高为199.9厘米(范围191.3至206.7厘米)。未观察到骨骺阻滞术有明显的副作用。除了降低最终身高外,骨骺阻滞术还使身体比例正常化,以坐骨下腿长/坐高比值表示。最终身高时,手术患者的该比值为0.96(范围0.90至1.01),对照为0.94(范围0.88至1.03)。
对于预计身材高大的男孩,可建议采用骨骺阻滞术来降低最终身高。该方法的另一个优点是身体比例正常化。