Shin Ii-Seon, Stewart Robert, Kim Jae-Min, Kim Sung-Wan, Yang Su-Jin, Shin Hee-Young, Jung Jae-Sung, Yoon Jin-Sang
Department of Psychiatry, Chonnam National University Medical School, Kwangju, Republic of Korea.
Int J Geriatr Psychiatry. 2005 Nov;20(11):1075-80. doi: 10.1002/gps.1401.
The association between the mutant allele of mitochondrial aldehyde dehydrogenase (ALDH22) and Alzheimer's disease (AD) has been controversial and only so far investigated in cross-sectional studies. This study aimed to investigate the longitudinal association between ALDH22 and incidence of AD.
Of 592 participants aged 65 or over without dementia at baseline, 510 (86%) were re-evaluated after 2.4 years and comprised the study sample. Baseline measures included: demographic characteristics, drinking behavior, cognitive function (MMSE), clinical diagnoses of dementia and AD, and genotype (ALDH2 and apolipoprotein E). At the follow up examination, alcohol related characteristics, MMSE and clinical diagnoses of dementia and AD were reassessed.
There were no significant associations between the ALDH2*2 and any cognitive outcomes (incidence of dementia or AD, or cognitive decline). These findings were not changed after adjustment for alcohol consumption. No interaction was found between ALDH2 and apolipoprotein E.
ALDH2*2 does not seem to be important in the etiology of dementia.
线粒体醛脱氢酶突变等位基因（ALDH22）与阿尔茨海默病（AD）之间的关联一直存在争议，迄今为止仅在横断面研究中进行过调查。本研究旨在探讨ALDH22与AD发病率之间的纵向关联。
在592名基线时无痴呆的65岁及以上参与者中，510名（86%）在2.4年后进行了重新评估，构成了研究样本。基线测量包括：人口统计学特征、饮酒行为、认知功能（简易精神状态检查表）、痴呆和AD的临床诊断以及基因型（ALDH2和载脂蛋白E）。在随访检查中，重新评估了与酒精相关的特征、简易精神状态检查表以及痴呆和AD的临床诊断。
ALDH2*2与任何认知结果（痴呆或AD的发病率或认知衰退）之间均无显著关联。在对饮酒量进行调整后，这些结果没有改变。未发现ALDH2与载脂蛋白E之间存在相互作用。
ALDH2*2在痴呆病因学中似乎并不重要。
