戊二醛诱发的职业性哮喘：特异性吸入激发试验引起的支气管肺泡灌洗液（BALF）成分以及BALF和血清克拉拉细胞蛋白（CC16）的变化
Glutaraldehyde-induced occupational asthma: BALF components and BALF and serum Clara cell protein (CC16) changes due to specific inhalatory provocation test.
作者信息
Palczynski Cezary, Walusiak Jolanta, Krakowiak Anna, Halatek Tadeusz, Ruta Urszula, Krawczyk-Adamus Patrycja, Wittczak Tomasz, Swiercz Radoslaw, Gorski Pawel, Rydzynski Konrad
机构信息
Department of Occupational Diseases, Centre of Occupational and Environmental Allergy, Nofer Institute of Occupational Medicine, 8 Teresy St, 90-950 Lodz, Poland.
出版信息
Occup Med (Lond). 2005 Oct;55(7):572-4. doi: 10.1093/occmed/kqi120.
OBJECTIVES
The purpose of this study was to evaluate bronchoalveolar lavage fluid (BALF) components and Clara cell protein (CC16) concentration in serum and BALF in patients with glutaraldehyde (GA)-induced asthma, before and after a specific inhalatory provocation test (SIPT) with GA, in comparison to atopic asthmatics and healthy individuals.
METHODS
Spirometry and bronchoalveolar lavage were performed before and after SIPT. The serum and BALF concentrations of CC16 and cytogram content in BALF were evaluated.
RESULTS
In GA-sensitized asthmatics, the level of CC16 in BALF and serum was significantly lower at 24 h after SIPT in comparison with the values recorded prior to the experiment. There was a significant increase in the proportion of eosinophils, basophils and lymphocytes in BALF of GA-sensitized asthmatics obtained after SIPT.
CONCLUSIONS
The determination of CC16 either in serum or in BALF is a non-invasive test to detect Clara cell damage.
目的
本研究旨在评估戊二醛（GA）诱导的哮喘患者在GA特异性吸入激发试验（SIPT）前后，支气管肺泡灌洗液（BALF）成分以及血清和BALF中克拉拉细胞蛋白（CC16）的浓度，并与特应性哮喘患者和健康个体进行比较。
方法
在SIPT前后进行肺功能测定和支气管肺泡灌洗。评估CC16的血清和BALF浓度以及BALF中的细胞图谱内容。
结果
在GA致敏的哮喘患者中，与实验前记录的值相比，SIPT后24小时BALF和血清中的CC16水平显著降低。SIPT后获得的GA致敏哮喘患者的BALF中嗜酸性粒细胞、嗜碱性粒细胞和淋巴细胞的比例显著增加。
结论
测定血清或BALF中的CC16是检测克拉拉细胞损伤的一种非侵入性试验。
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