一些新型1,3-或1,4-双（吡喃葡萄糖基-1,2,4-三唑-5-硫基）丙烷或丁烷作为潜在抗菌剂的合成。
Synthesis of some new 1,3/ or 1,4-bis(glucopyranosyl-1,2,4-triazol-5-ylthio)propanes/ or butanes as potential antimicrobial agents.
作者信息
Abbas Ashraf A, Khalil Nasser S A M
机构信息
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2005;24(9):1353-72. doi: 10.1080/15257770500230632.
Glucosidation of the appropriate 1,3 or 1,4-bis(4-amino or arylideneamino-2,4-dihydro-3-thioxo-3H-1,2,4-triazol-5-ylthio)propanes or butanes with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide followed by chromatographic separation gave the corresponding N-, S-, and N,S-bis(glucosides). Chemical transformation leading to new functionalities has been achieved. Antimicrobial screening of 10 selected compounds resulted in their activity against Aspergillus fumigatus, Penicillium italicum, Syncephalastrum racemosum, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.
将合适的1,3或1,4 - 双（4 - 氨基或亚芳基氨基 - 2,4 - 二氢 - 3 - 硫代 - 3H - 1,2,4 - 三唑 - 5 - 基硫代）丙烷或丁烷与2,3,4,6 - 四 - O - 乙酰基 - α - D - 吡喃葡萄糖基溴进行葡糖基化反应，然后通过色谱分离得到相应的N - 、S - 和N,S - 双（葡糖苷）。已经实现了导致新官能团的化学转化。对10种选定化合物进行抗菌筛选，结果表明它们对烟曲霉、意大利青霉、总状毛霉、白色念珠菌、金黄色葡萄球菌、铜绿假单胞菌、枯草芽孢杆菌和大肠杆菌具有活性。
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