Sakurai Ryota, Ako Junya, Morino Yoshihiro, Sonoda Shinjo, Kaneda Hideaki, Terashima Mitsuyasu, Hassan Ali H M, Leon Martin B, Moses Jeffrey W, Popma Jeffrey J, Bonneau Heidi N, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, California, USA.
Am J Cardiol. 2005 Nov 1;96(9):1251-3. doi: 10.1016/j.amjcard.2005.06.066. Epub 2005 Sep 6.
To study the interaction of the sirolimus-eluting stent and vessel margins, we analyzed the intravascular ultrasound parameters in 317 edges of 167 stents having 18 edge stenoses at 8 months of follow-up from the SIRIUS trial. Of the baseline parameters, a larger reference percentage of plaque area and a larger edge stent area/reference minimum lumen area were associated with edge stenosis in the sirolimus-eluting stent cohort compared with the incidence of edge stenosis in the bare metal stent cohort. Thus, full lesion coverage and matching the stented segment properly to the adjacent segment using intravascular ultrasound guidance may improve sirolimus-eluting stent implantation efficacy further.
为研究西罗莫司洗脱支架与血管边缘的相互作用，我们从西罗莫司洗脱支架治疗冠状动脉狭窄的随机对照试验（SIRIUS试验）中，分析了167个支架的317个边缘在随访8个月时的血管内超声参数，这些支架中有18处边缘狭窄。在基线参数中，与裸金属支架队列中的边缘狭窄发生率相比，西罗莫司洗脱支架队列中更大的斑块面积参考百分比以及更大的边缘支架面积/参考最小管腔面积与边缘狭窄相关。因此，完全覆盖病变并在血管内超声引导下使支架段与相邻段正确匹配，可能会进一步提高西罗莫司洗脱支架植入的疗效。
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