Meunier N, Feillet-Coudray C, Rambeau M, Andriollo-Sanchez M, Brandolini-Bunlon M, Coulter S J, Cashman K D, Mazur A, Coudray C
Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques et Micro-nutriments, I.N.R.A., Theix, St Genès Champanelle, France.
Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S48-52. doi: 10.1038/sj.ejcn.1602298.
Adjustments in intestinal absorption and losses of zinc (Zn) are thought to maintain Zn homeostasis when dietary intake levels are altered. Zn status may also influence efficiency of intestinal Zn absorption.
To determine the impact of dietary intake and status of some micronutrients on Zn absorption in late middle-aged men.
Dietary intake and status of Zn, Cu, Fe, vitamin A, C and fibre, and absorption of Zn were measured in 48 men, aged 58-68 y, confined to a metabolic unit and consuming a typical French diet. Dietary intake was estimated using 4-day food-intake records (including the weekend) and the GENI program. To assess Zn status, serum, erythrocyte, urine Zn levels and serum alkaline phosphatase activity were determined. Zn absorption was determined using the isotope double-labelling method. Zn stable isotopic ratios were measured in plasma samples collected before and 48 h after isotope administration using ICP/MS.
Zn intake within the group of men varied from 5.7 to 20.5 mg/day and averaged 12.9 mg/day. Serum Zn level varied from 10 to 18 micromol/l and averaged 12.9 micromol/l. Zn absorption varied from 12 to 46% and averaged 29.7%. Zn absorption was not significantly (P > 0.05) correlated with Zn intake or with any of the Zn status parameters. Zn absorption was only slightly negatively correlated with serum and erythrocyte Zn levels and with serum Fe and ferritin levels in this study.
Zn dietary intake and Zn absorption were satisfactory and led to an adequate Zn status in this population.
当饮食摄入量改变时,肠道对锌(Zn)的吸收和锌的流失调节被认为可维持锌的体内平衡。锌状态也可能影响肠道锌吸收效率。
确定某些微量营养素的饮食摄入量和状态对中老年男性锌吸收的影响。
对48名年龄在58 - 68岁的男性进行了研究,他们被限制在一个代谢单元内,食用典型的法国饮食,测量了锌、铜、铁、维生素A、C和纤维的饮食摄入量及状态,以及锌的吸收情况。饮食摄入量通过4天的食物摄入记录(包括周末)和GENI程序进行估算。为评估锌状态,测定了血清、红细胞、尿液中的锌水平以及血清碱性磷酸酶活性。使用同位素双标记法测定锌吸收。使用电感耦合等离子体质谱仪(ICP/MS)测量同位素给药前和给药后48小时采集的血浆样本中的锌稳定同位素比率。
该组男性的锌摄入量在5.7至20.5毫克/天之间,平均为12.9毫克/天。血清锌水平在10至18微摩尔/升之间,平均为12.9微摩尔/升。锌吸收在12%至46%之间,平均为29.7%。锌吸收与锌摄入量或任何锌状态参数均无显著相关性(P > 0.05)。在本研究中,锌吸收仅与血清和红细胞锌水平以及血清铁和铁蛋白水平呈轻微负相关。
该人群的锌饮食摄入量和锌吸收情况良好,锌状态充足。