Andriollo-Sanchez M, Hininger-Favier I, Meunier N, Toti E, Zaccaria M, Brandolini-Bunlon M, Polito A, O'Connor J M, Ferry M, Coudray C, Roussel A-M
Laboratoire de Nutrition Vieillissement et Maladies Cardiovasculaires, Faculté de Pharmacie, Université de Joseph Fourier, Domaine de la Merci, La Tronche, France.
Eur J Clin Nutr. 2005 Nov;59 Suppl 2:S37-41. doi: 10.1038/sj.ejcn.1602296.
Inadequate intakes of micronutrients in elderly negatively affect the nutritional status. Zinc is an essential micronutrient in the elderly, especially in relation to its impact on immune function, bone mass, cognitive function and oxidative stress. However, data are lacking on zinc intake and status during normal ageing. In this study, we evaluate the intake and status of zinc in late middle-aged and older free-living subjects.
Dietary zinc intake and zinc status in 188 middle-aged subjects from Clermont-Ferrand (Fr) and Coleraine (UK), and in 199 older subjects from Grenoble (Fr) and Roma (It) were assessed at the entry in the ZENITH study.
In relation to the zinc RDA for people older than 55 y, zinc intakes in most of the middle-aged and older subjects (more than 96%) in the present study were adequate. Older people had significantly lower (P < 0.01) energy intakes as compared to middle-aged. Zinc intake expressed per MJ was also significantly (P < 0.01) higher in older people compared to middle-aged. Erythrocyte and urinary zinc concentrations were significantly (P < 0.001) higher in middle-aged subjects compared to older ones. The prevalence of biological Zn deficiency in free-living ageing European people was low (<5%).
The results of the present study showed a relatively low prevalence of zinc deficiencies in healthy free-living late middle-age and older subjects. These results should be useful for health professionals to have reference data on zinc intake and status for a healthy ageing.
老年人微量营养素摄入不足会对营养状况产生负面影响。锌是老年人必需的微量营养素，尤其是在其对免疫功能、骨量、认知功能和氧化应激的影响方面。然而，关于正常衰老过程中锌的摄入量和状况的数据尚缺乏。在本研究中，我们评估了自由生活的中老年受试者的锌摄入量和状况。
在ZENITH研究开始时，对来自法国克莱蒙费朗和英国科勒雷恩的188名中年受试者以及来自法国格勒诺布尔和意大利罗马的199名老年受试者的膳食锌摄入量和锌状况进行了评估。
与55岁以上人群的锌推荐膳食摄入量（RDA）相比，本研究中大多数中年和老年受试者（超过96%）的锌摄入量充足。老年人的能量摄入量明显低于中年人（P < 0.01）。按每兆焦耳计算，老年人的锌摄入量也明显高于中年人（P < 0.01）。中年受试者的红细胞和尿锌浓度明显高于老年受试者（P < 0.001）。自由生活的欧洲老年人中生物性锌缺乏的患病率较低（<5%）。
本研究结果表明，健康的自由生活的中老年受试者中锌缺乏的患病率相对较低。这些结果对于健康专业人员获取健康老龄化的锌摄入量和状况参考数据应是有用的。
