Rockman S, Begley C G, Kannourakis G, Mann G J, Dobrovic A N, Kefford R F, McGrath K
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
Leukemia. 1992 Jul;6(7):623-5.
The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain-reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.
SCL基因编码一种转录因子，属于螺旋-环-螺旋（HLH）家族成员，据报道，高达25%的T细胞急性淋巴细胞白血病（T-ALL）与之有关。我们已对120多种原发性人类肿瘤进行了研究，包括黑色素瘤、髓系和淋巴系白血病以及其他实体瘤，未发现涉及SCL重排的证据。这些肿瘤中SCL的低水平表达（通过基于聚合酶链反应的方法评估）进一步支持了这些结果。我们得出结论，在髓系白血病和黑色素瘤中，SCL重排/易位并随后激活的情况很少发生。
