Hoszek Anders, Struzycka Isabel, Jozefowicz Agata, Wojcieszek Danuta, Wierzbicka Maria, Wretlind Katarina, Ericson Dan
Department of Cariology, Faculty of Odontology, Malmö University, Sweden.
Swed Dent J. 2005;29(3):89-96.
Glass ionomer cement with addition of chlorhexidine used as a varnish on tooth surfaces has been shown to reduce the number of interproximal mutans streptococci (ms). The effect of a single application of such a varnish containing 2.5% chlorhexidine on occlusal caries development of the first permanent molars on 6-year-old children in a high caries incidence area was investigated. The children were examined according to WHO criteria and 262 children with 2 caries free contra-lateral molars were selected for treatment. Salivary ms samples were collected using the Strip-mutans (SM) method. After brushing the occlusal surfaces with a toothbrush and pumice in water slurry, rinsing and drying with a cotton roll, glass ionomer cement containing chlorhexidine (GI-CHX) and glass ionomer (GI) were applied randomly with a micro brush and the varnish was covered with occlusal wax. At baseline, the mean defs was 18.18 and DMFS was 0.25 and after one year 18.24 and 0.83 respectively. The salivary ms scores were high or very high (SM 2 and 3) in 85.6% at baseline. At the one-year follow up, the GI-CHX and GI materials could not be detected in the fissures. Also, a large number of fissure sealants had been placed in the molars outside the study protocol; thus 4% of the GI-CHX and GI, and 70% of the untreated were sealed at year one. Overall, there was no significant difference between the caries-reducing effect of GI-CHX and GI, but a trend towards a higher effect was seen for GI-CHX. Excluding the sealed molars the reduction was 74% in the GI-CHX-group, and 71% in the GI-group.
Addition of 2.5% chlorhexidine to glass ionomer did not seem to increase the caries-reducing effect of the varnish in this high caries incidence population.
已证明，添加洗必泰的玻璃离子水门汀用作牙齿表面的清漆可减少邻面变形链球菌（ms）的数量。研究了单次应用含2.5%洗必泰的这种清漆对高龋齿发病率地区6岁儿童第一恒磨牙咬合面龋齿发展的影响。根据世界卫生组织标准对儿童进行检查，选择262名有2颗无龋对侧磨牙的儿童进行治疗。使用变形链球菌试纸条（SM）法收集唾液ms样本。用牙刷和含水浆的浮石刷洗咬合面，用棉卷冲洗并干燥后，用微型刷随机涂抹含洗必泰的玻璃离子水门汀（GI-CHX）和玻璃离子水门汀（GI），并用咬合蜡覆盖清漆。基线时，平均defs为18.18，DMFS为0.25，一年后分别为18.24和0.83。基线时85.6%的唾液ms评分高或非常高（SM 2和3）。在一年的随访中，在裂隙中未检测到GI-CHX和GI材料。此外，大量磨牙在研究方案之外进行了窝沟封闭；因此，在第一年，GI-CHX和GI组中有4%以及未治疗组中有70%进行了封闭。总体而言，GI-CHX和GI的防龋效果之间没有显著差异，但GI-CHX有效果更高的趋势。排除封闭的磨牙后，GI-CHX组的龋减少率为74%，GI组为71%。
在这个高龋齿发病率人群中，向玻璃离子中添加2.5%的洗必泰似乎并未增加清漆的防龋效果。
