Holden Wendy, Joseph Joseph
Expert Opin Drug Saf. 2005 Nov;4(6):969-74. doi: 10.1517/14740338.4.6.969.
Many patients with rheumatological conditions use herbal remedies as an adjunct to their conventional antirheumatic medication, often without seeking advice. Herbal remedies are exempt from the usual drug safety requirements and may be a cause of both adverse effects and drug interactions. Data on interactions between herbal remedies and conventional antirheumatic medication is scarce. Reasons include a perception that herbal remedies are safe, a lack of reporting by patients and healthcare professionals and a lack of knowledge about the pharmacology and composition of herbal remedies, as well as adulteration. Interactions are likely between herbal remedies with antiplatelet or nephrotoxic effects and NSAIDs, hepatotoxic herbal remedies and disease-modifying antirheumatic medication, and between St. John's Wort and cyclosporin.
许多患有风湿性疾病的患者将草药疗法作为其传统抗风湿药物的辅助手段，而且往往未征求专业意见。草药疗法不受常规药物安全要求的约束，可能会导致不良反应和药物相互作用。关于草药疗法与传统抗风湿药物之间相互作用的数据很少。原因包括认为草药疗法是安全的观念、患者和医护人员缺乏报告，以及对草药疗法的药理学和成分缺乏了解，还有掺假情况。具有抗血小板或肾毒性作用的草药疗法与非甾体抗炎药之间、具有肝毒性的草药疗法与改善病情的抗风湿药物之间，以及圣约翰草与环孢素之间可能会发生相互作用。
