Tamasawa Naoki, Matsui Jun, Murakami Hiroshi, Tanabe Jutaro, Matsuki Kohta, Ogawa Yoshiji, Ikeda Yasuyuki, Takagi Atsuko, Suda Toshihiro
Third Department of Internal Medicine, Hirosaki University School of Medicine, Zaifu-5, Hirosaki, Aomori 036-8562, Japan.
Diabetes Res Clin Pract. 2006 Apr;72(1):6-11. doi: 10.1016/j.diabres.2005.08.010. Epub 2005 Oct 26.
Elevations in plasma triglyceride (TG) and free fatty acid (FFA) concentrations are generally thought to play a role in the pathogenesis of insulin-resistant diabetes. The objective of this study was to investigate the relationship between hypertriglyceridemia and glucose-stimulated insulin responsiveness in non-diabetic patients. Forty subjects were divided into three BMI-matched groups as follows: one group consisted of 8 patients with a lipoprotein lipase (LPL) deficiency, another consisted of 12 patients with hypertriglyceridemia and a third consisted of 20 subjects with normal TG levels. In response to a 75 g oral glucose tolerance test, plasma insulin levels in the LPL-deficient subjects were higher (106+/-11 microU/ml) than those in the hypertriglyceridemic (69+/-16 microU/ml) and normolipidemic (29+/-3 microU/ml) subjects, at 30 min. On the other hand, their plasma glucose levels (127+/-6 mg/dl) were less than those seen in the normolipidemic group (165+/-9 mg/dl) after 90 min. Thus, LPL-deficient subjects with hypertriglyceridemia displayed an enhanced glucose-stimulated insulin response as well as lower blood glucose levels, the latter of which is not generally seen in those with hypertriglyceridemia and normolipidemia.
血浆甘油三酯（TG）和游离脂肪酸（FFA）浓度升高通常被认为在胰岛素抵抗性糖尿病的发病机制中起作用。本研究的目的是调查非糖尿病患者中高甘油三酯血症与葡萄糖刺激的胰岛素反应性之间的关系。40名受试者按体重指数（BMI）匹配分为三组：一组由8名脂蛋白脂肪酶（LPL）缺乏患者组成，另一组由12名高甘油三酯血症患者组成，第三组由20名甘油三酯水平正常的受试者组成。在75克口服葡萄糖耐量试验中，30分钟时，LPL缺乏受试者的血浆胰岛素水平（106±11微单位/毫升）高于高甘油三酯血症（69±16微单位/毫升）和血脂正常（29±3微单位/毫升）的受试者。另一方面，90分钟后，他们的血浆葡萄糖水平（127±6毫克/分升）低于血脂正常组（165±9毫克/分升）。因此，患有高甘油三酯血症的LPL缺乏受试者表现出增强的葡萄糖刺激胰岛素反应以及较低的血糖水平，后者在高甘油三酯血症和血脂正常者中通常未见。
