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氯氮平治疗患者的麻醉相关问题

Implications for anaesthesia in a patient established on clozapine treatment.

作者信息

Doherty J, Bell P F, King D J

机构信息

Department of Anaesthetics, Royal Victoria Hospital, Musgrave Park Hospital, Belfast, Northern Ireland.

出版信息

Int J Obstet Anesth. 2006 Jan;15(1):59-62. doi: 10.1016/j.ijoa.2005.04.015. Epub 2005 Oct 26.

Abstract

Clozapine is an atypical antipsychotic agent with a novel pharmacological profile and multiple clinical properties. Because of its side effects, it is recommended in treatment of severe resistant schizophrenia for which purpose it is remarkably effective. Little is known about the safety profile of clozapine during pregnancy and labour and because it is now used more commonly to manage schizophrenia, it is important that we as anaesthetists are aware of its many interactions and potential side effects. We present a case of a successful emergency caesarean section in a schizophrenic patient on clozapine treatment.

摘要

氯氮平是一种具有独特药理特性和多种临床特性的非典型抗精神病药物。由于其副作用,它被推荐用于治疗重度难治性精神分裂症,且在这一治疗目的上效果显著。关于氯氮平在妊娠和分娩期间的安全性概况知之甚少,并且由于它现在更常用于治疗精神分裂症,作为麻醉医生,我们了解其众多相互作用和潜在副作用非常重要。我们报告一例正在接受氯氮平治疗的精神分裂症患者成功进行急诊剖宫产的病例。

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