Muzzalupo Rita, Trombino Sonia, Iemma Francesca, Puoci Francesco, La Mesa Camillo, Picci Nevio
Department of Pharmaceutical Science, Calabria University, Ponte P. Bucci, Ed. Polifunzionale, 87030 Rende, Italy.
Colloids Surf B Biointerfaces. 2005 Dec 10;46(2):78-83. doi: 10.1016/j.colsurfb.2005.09.003. Epub 2005 Oct 28.
Vesicular formulations (liposomes and niosomes) play an increasingly important role since they can be used as drug delivery and targeting systems. We described the formation of two niosomal systems based on synthetic bolaform surfactants (4,7,10,13-pentaoxa-16-aza-cyclooctadecane)-hexadecanedioc acid diamide (BD-16) and alpha,omega-(4,7,10,13-pentaoxa-16-aza-cyclooctadecane)-hexadecane (BC-16). Systems containing BD-16 or BC-16 and different amount of cholesterol (CH) were prepared by aqueous dispersion of films, followed by examination of methylene blue (MB) entrapment, particle size and morphology. Indeed, we also studied the hydration in the distilled water and physiological solution, in order to investigate the complexing ability on vesicle formation. The results obtained in this study show a high encapsulation capacity and this ability and the size depends on cholesterol content.
囊泡制剂（脂质体和非离子表面活性剂泡囊）发挥着越来越重要的作用，因为它们可用作药物递送和靶向系统。我们描述了基于合成bolaform表面活性剂（4,7,10,13-五氧杂-16-氮杂环十八烷）-十六烷二酸二酰胺（BD-16）和α,ω-（4,7,10,13-五氧杂-16-氮杂环十八烷）-十六烷（BC-16）的两种非离子表面活性剂泡囊系统的形成。通过薄膜的水分散法制备了含有BD-16或BC-16以及不同量胆固醇（CH）的系统，随后检测亚甲蓝（MB）包封率、粒径和形态。实际上，我们还研究了在蒸馏水和生理溶液中的水合作用，以研究其对囊泡形成的络合能力。本研究获得的结果显示出高包封能力，并且这种能力和大小取决于胆固醇含量。
