为在非洲开展的二期/三期HIV疫苗试验做准备。

Preparing for phase II/III HIV vaccine trials in Africa.

作者信息

Vardas Eftyhia, Buttò Stefano, Glashoff Richard, Malnati Mauro S, Poli Guido, Clerici Mario

机构信息

Perinatal HIV Research Unit, University of the Witwatersrand, PO Box 114, Diepkloof 1864, Johannesburg, South Africa.

出版信息

Microbes Infect. 2005 Nov;7(14):1436-44. doi: 10.1016/j.micinf.2005.07.021. Epub 2005 Sep 26.

DOI:10.1016/j.micinf.2005.07.021

PMID:16257561

Abstract

Before performing phase II/III clinical trials in Africa, preliminary studies, including assessment and building up of clinical and laboratory infrastructures, estimates of human immunodeficiency virus incidence, investigation of the background immune response, and evaluation of the cross-clade immune response, need to be done. Plans and ongoing work in the context of the AIDS Vaccine Integrated Project and some preliminary data are presented.

摘要

在非洲开展II/III期临床试验之前，需要进行一些初步研究，包括评估和建立临床与实验室基础设施、估计人类免疫缺陷病毒发病率、调查背景免疫反应以及评估跨亚型免疫反应。本文介绍了艾滋病疫苗综合项目背景下的计划和正在进行的工作以及一些初步数据。