ADAM33：哮喘发病机制中一个新发现的基因。

ADAM33: a newly identified gene in the pathogenesis of asthma.

作者信息

Holgate Stephen T, Davies Donna E, Powell Rob M, Holloway John W

机构信息

Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK.

出版信息

Immunol Allergy Clin North Am. 2005 Nov;25(4):655-68. doi: 10.1016/j.iac.2005.07.003.

DOI:10.1016/j.iac.2005.07.003

PMID:16257631

Abstract

There is much to find out about this fascinating and complex molecule in relation to the development and progression of asthma. Added to it are three further new asthma/allergy genes identified by positional cloning: PDH Finger Protein II (PHF11) on chromosome 13q14, which encodes NY-REN-34 a protein first described in patients with renal cell carcinoma [67]; Dipeptidyl diptidase 10 (DDP10) on chromosome 2q14 [68]; and G protein-coupled receptor for asthma susceptibility (GPRA) on chromosome 7p [69]. For each of these genes, as is the case for ADAM33, determining their normal function(s) and how these become disordered in asthma is the future challenge.

摘要

关于这种迷人而复杂的分子与哮喘的发生和发展，仍有许多有待发现的地方。此外，通过定位克隆又鉴定出另外三个新的哮喘/过敏相关基因：位于13q14染色体上的PDH指蛋白II（PHF11），它编码NY-REN-34，一种最初在肾细胞癌患者中发现的蛋白质[67]；位于2q14染色体上的二肽基肽酶10（DDP10）[68]；以及位于7p染色体上的哮喘易感性G蛋白偶联受体（GPRA）[69]。对于这些基因中的每一个，就像ADAM33的情况一样，确定它们的正常功能以及这些功能在哮喘中如何紊乱是未来的挑战。