Bauman Glenn, Shaw Edward G
University of Western Ontario, London, Ontario N6A 4L6, Canada.
Clin Adv Hematol Oncol. 2003 Sep;1(9):546-53.
The question of optimal management of patients with low-grade gliomas continues to generate considerable controversy. Retrospective studies have helped delineate prognostic factors for patients with these tumors as well as the relative efficacy of surgery, radiation and chemotherapy. Results of recently completed and ongoing prospective, multi-institutional trials will help guide the treatment of these patients in the future. Other advances include the molecular characterization of these tumors that should assist in selection of existing and development of future therapies.
低级别胶质瘤患者的最佳管理问题仍存在诸多争议。回顾性研究有助于明确这些肿瘤患者的预后因素以及手术、放疗和化疗的相对疗效。近期完成及正在进行的前瞻性多机构试验结果将有助于指导未来这些患者的治疗。其他进展包括对这些肿瘤的分子特征描述，这应有助于现有治疗方法的选择及未来治疗方法的研发。
