Low-grade glioma: current management and controversies.

The question of optimal management of patients with low-grade gliomas continues to generate considerable controversy. Retrospective studies have helped delineate prognostic factors for patients with these tumors as well as the relative efficacy of surgery, radiation and chemotherapy. Results of recently completed and ongoing prospective, multi-institutional trials will help guide the treatment of these patients in the future. Other advances include the molecular characterization of these tumors that should assist in selection of existing and development of future therapies.