Triplett Douglas A
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Clin Adv Hematol Oncol. 2003 Dec;1(12):726-30.
Antiphospholipid antibodies (APAs) have been associated with thromboembolic events. Since they were fi rst described in 1906, APAs have been the subject of multidisciplinary studies seeking to link them to potential pathophysiologic mechanisms. This review summarizes the different types of APAs, antigenic targets, clinical complications associated with APAs, and APA syndrome. In addition, the currently available methods for laboratory identification of lupus anticoagulants are discussed, as is the laboratory diagnosis of anticardiolipin antibodies.
抗磷脂抗体（APAs）与血栓栓塞事件有关。自1906年首次被描述以来，APAs一直是多学科研究的主题，旨在将它们与潜在的病理生理机制联系起来。本综述总结了不同类型的APAs、抗原靶点、与APAs相关的临床并发症以及APA综合征。此外，还讨论了目前用于实验室鉴定狼疮抗凝物的方法以及抗心磷脂抗体的实验室诊断。
