Lanser M J, Sussman S A, Frazer K
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco 94117-0958.
Otolaryngol Clin North Am. 1992 Jun;25(3):499-520.
This article reviews the epidemiology of both unilateral and bilateral (NF-2) acoustic tumors. The growth rate of acoustic tumors is examined from a clinical, radiographic, and laboratory perspective. The anatomic, histologic, and biochemical considerations as well as the influences of sex hormones on acoustic tumor formation are reviewed. Also presented are an update on the laboratory search for the NF-2 gene on chromosome 22 and recently identified DNA markers. Predictions are made concerning the potential future applications of genetic testing for prenatal or presymptomatic diagnosis of the disease that causes bilateral acoustic tumors.
本文综述了单侧及双侧（神经纤维瘤病2型）听神经瘤的流行病学。从临床、影像学和实验室角度研究了听神经瘤的生长速率。综述了解剖学、组织学和生物化学方面的因素以及性激素对听神经瘤形成的影响。还介绍了在22号染色体上寻找神经纤维瘤病2型基因的实验室研究进展以及最近鉴定出的DNA标记。对基因检测在导致双侧听神经瘤疾病的产前或症状前诊断中的潜在未来应用进行了预测。
