Almeida Antonio Nogueira de, Tavares Cristiane, Tibano Adriana, Sasaki Seigi, Murata Kazuco Nakai, Marino Raul
Instituto Neurológico de São Paulo, Hospital São Joaquim, Real e Benemérita Sociedade Portuguesa de Beneficência, São Paulo, SP, Brasil.
Arq Neuropsiquiatr. 2005 Sep;63(3B):748-50. doi: 10.1590/s0004-282x2005000500005. Epub 2005 Oct 18.
This paper reports the use of dexmedetomidine in three epileptic patients with cavernous angiomas that underwent awake surgery in order to map their speech areas.
Loading dose of dexmedetomidine varied from 1 microg/Kg/h to 3 microg/Kg/h over 20 minutes and maintenance dose from 0.4 microg/Kg/h to 0.8 microg/Kg/h.
There was no occurrence of hemodynamic instability, convulsions or respiratory depression. Patients tolerated well the procedure.
Dexmedetomidine was useful for awake craniotomy as it decreased patients level of consciousness but did not produce agitation. Laryngeal mask was not necessary to keep air ventilation.
本文报道了右美托咪定在3例患有海绵状血管瘤的癫痫患者清醒手术中用于定位其语言区域的情况。
右美托咪定的负荷剂量在20分钟内从1微克/千克/小时变化至3微克/千克/小时，维持剂量为0.4微克/千克/小时至0.8微克/千克/小时。
未出现血流动力学不稳定、惊厥或呼吸抑制。患者对该手术耐受性良好。
右美托咪定对清醒开颅手术有用，因为它降低了患者的意识水平但未引起躁动。无需喉罩来维持通气。
