Gruber Michael P, Geraci Mark W
University of Colorado Health Sciences Center, USA.
J Insur Med. 2005;37(3):190-200.
Functional genomics is the science that defines the function of newly identified genes and translates this knowledge into related health and disease. Functional genomics is complex, involving multiple scientific disciplines including computational biology, genetics, physiology, structural biology, and molecular and cell biology. Due to its inherent complexity, the National Institutes of Health (NIH) has termed functional genomics "the science of collaboration." This paper will review microarray gene expression analysis, proteomics, and the impact of molecular medical genetics on medical care.
功能基因组学是一门确定新发现基因的功能并将这一知识转化为相关健康与疾病问题的科学。功能基因组学十分复杂，涉及包括计算生物学、遗传学、生理学、结构生物学以及分子与细胞生物学在内的多个科学学科。由于其内在的复杂性，美国国立卫生研究院（NIH）将功能基因组学称为“合作的科学”。本文将综述微阵列基因表达分析、蛋白质组学以及分子医学遗传学对医疗保健的影响。
