Karadag Figen, Sar Vedat, Tamar-Gurol Defne, Evren Cuneyt, Karagoz Mustafa, Erkiran Murat
Research, Treatment and Training Center for Alcohol and Substance Dependency (AMATEM) and Neurosis Clinic, Bakirkoy State Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey.
J Clin Psychiatry. 2005 Oct;66(10):1247-53. doi: 10.4088/jcp.v66n1007.
To determine the prevalence of dissociative disorders among inpatients with alcohol or drug dependency.
The Dissociative Experiences Scale was used to screen 215 consecutive inpatients admitted to the dependency treatment center of a large mental hospital over a 1-year period (March 1, 2003, to March 31, 2004). Patients who had scores of 30.0 or above were compared with patients who scored below 10.0 on the scale. The patients in both groups were then evaluated using the Dissociative Disorders Interview Schedule and the Structured Clinical Interview for DSM-IV Dissociative Disorders. The interviewers were blind to the Dissociative Experiences Scale scores.
Of the patients, 36.7% had a Dissociative Experiences Scale score of 30.0 or above. The prevalence of DSM-IV dissociative disorders was 17.2% (N = 37). On average, 64.9% of these patients' dissociative experiences had started 3.6 years (SD = 2.9; range, 1.0-11.0 years) before onset of the substance use. Patients with dissociative disorders were younger, and the mean duration of their remission periods was shorter. Dissociative disorder patients tended to use more than 1 substance, and drugs were used more frequently than alcohol in this group. The frequency of borderline personality disorder, somatization disorder, history of suicide attempt, and childhood abuse and neglect occurred more frequently in the dissociative disorder group than in the nondissociative disorder group. History of suicide attempt (p = .005), female sex (p = .050), and childhood emotional abuse (p = .010) were significant predictors of a dissociative disorder diagnosis. Significantly more patients with dissociative disorders stopped their treatment prematurely (p < .001).
Impact of dissociative disorders on development and treatment of substance dependency requires further study.
确定酒精或药物依赖住院患者中分离性障碍的患病率。
采用分离体验量表对一家大型精神病医院依赖治疗中心在1年期间(2003年3月1日至2004年3月31日)连续收治的215例住院患者进行筛查。将量表得分30.0及以上的患者与得分低于10.0的患者进行比较。然后使用分离性障碍访谈量表和DSM-IV分离性障碍结构化临床访谈对两组患者进行评估。访谈者对分离体验量表得分不知情。
患者中,36.7%的分离体验量表得分在30.0及以上。DSM-IV分离性障碍的患病率为17.2%(N = 37)。这些患者平均64.9%的分离体验在物质使用开始前3.6年(标准差 = 2.9;范围,1.0 - 11.0年)就已开始。分离性障碍患者更年轻,缓解期平均持续时间更短。分离性障碍患者倾向于使用不止一种物质,且该组中使用药物比使用酒精更频繁。边缘性人格障碍、躯体化障碍、自杀未遂史以及童年期虐待和忽视的发生率在分离性障碍组比非分离性障碍组更高。自杀未遂史(p = .005)、女性(p = .050)和童年期情感虐待(p = .010)是分离性障碍诊断的显著预测因素。分离性障碍患者过早停止治疗的比例显著更高(p < .001)。
分离性障碍对物质依赖的发展和治疗的影响需要进一步研究。