吲达帕胺相关的QT间期延长和尖端扭转型室性心动过速。

QT interval prolongation and torsade de pointes associated with indapamide.

作者信息

Letsas Konstantinos P, Alexanian Ioannis P, Pappas Loukas K, Kounas Stavros P, Efremidis Michalis, Sideris Antonios, Kardaras Fotis

出版信息

Int J Cardiol. 2006 Oct 10;112(3):373-4. doi: 10.1016/j.ijcard.2005.07.055. Epub 2005 Nov 2.

DOI:10.1016/j.ijcard.2005.07.055

PMID:16260053

Abstract

Direct blockade of the delayed rectifier repolarising potassium current is the major underlying mechanism of drug-induced QT interval prolongation. Indapamide is a well known blocker of the slow component of the delayed rectifier current leading to prolongation of cardiac repolarization. The case of an acquired long QT and torsade de pointes ventricular tachycardia in a woman with systemic lupus erythematosus and hypertension receiving prednisolone and indapamide, respectively, is described in the present report.

摘要

直接阻断延迟整流器复极化钾电流是药物诱导的QT间期延长的主要潜在机制。吲达帕胺是一种众所周知的延迟整流电流慢成分阻滞剂，可导致心脏复极化延长。本报告描述了一名患有系统性红斑狼疮和高血压的女性，分别接受泼尼松龙和吲达帕胺治疗后发生获得性长QT和尖端扭转型室性心动过速的病例。