Polig E, Jee W S, Setterberg R B, Johnson F
Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie von Spaltstoffen, Germany.
Radiat Res. 1992 Jul;131(1):24-34.
Young adult beagle dogs received a single injection of 38.1 kBq/kg body wt 226Ra and were serially sacrificed at 4 to 2955 days postinjection. Samples of sites of trabecular bone in the lumbar vertebral body, proximal ulna, and distal femoral metaphysis and epiphysis were analyzed autoradiographically. The time-dependent changes in the average 226Ra concentrations in the four regions were analyzed in terms of a compartmental model. The clearance rate from the lumbar vertebral body was about four times more rapid than for the proximal ulna and distal femoral epiphysis. Ratios of hotspot to diffuse label concentrations varied from about 10 to 23. The dose rate to the endosteum ranged between 8.7 and 39.5 mGy/day initially and 4 and 10.5 mGy/day toward the end of the observation period. Mean marrow dose rates were lower by a factor of 3 to 9.5. During their residence time the nuclei of bone lining cells receive a maximum dose of 8 Gy in the proximal ulna (2955 days after injection) and a minimum dose of 0.63 Gy in the lumbar vertebra (2955 days after injection). This corresponds on the average to 17 and 1.4 alpha-particle hits to the cell nuclei, respectively.
成年比格犬接受了一次38.1 kBq/kg体重的226镭注射，并在注射后4至2955天被连续处死。对腰椎椎体、尺骨近端以及股骨远端干骺端和骨骺的小梁骨部位样本进行了放射自显影分析。根据房室模型分析了这四个区域中平均226镭浓度随时间的变化。腰椎椎体的清除率比尺骨近端和股骨远端骨骺快约四倍。热点与弥散标记浓度的比值在约10至23之间。骨内膜的剂量率最初在8.7至39.5 mGy/天之间，在观察期结束时为4至10.5 mGy/天。平均骨髓剂量率低3至9.5倍。在其停留期间，骨衬细胞的细胞核在尺骨近端（注射后2955天）接受的最大剂量为8 Gy，在腰椎（注射后2955天）接受的最小剂量为0.63 Gy。这平均分别相当于细胞核受到17次和1.4次α粒子撞击。
