Monestier M, Kotzin B L
Garden State Cancer Center, Newark, New Jersey.
Rheum Dis Clin North Am. 1992 May;18(2):415-36.
Antihistone antibodies are some of the most frequent autoantibodies in rheumatic diseases and can represent useful diagnostic markers in some autoimmune syndromes. Histone epitopes are often located in accessible regions of chromatin or are conformational determinants resulting from the association of several components. These observations and studies with murine models of lupus strongly support the view that histones play a direct stimulatory role in triggering autoantibody production.
抗组蛋白抗体是风湿性疾病中最常见的自身抗体之一，在某些自身免疫综合征中可作为有用的诊断标志物。组蛋白表位通常位于染色质的可及区域，或是由几种成分结合产生的构象决定簇。这些观察结果以及对狼疮小鼠模型的研究有力地支持了组蛋白在触发自身抗体产生中起直接刺激作用的观点。
